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19 Cards in this Set
- Front
- Back
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Question
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answer
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The function of many proteins involve ...
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the reversible binding of other molecules
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A molecule bound reversibly by a protein is called
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a ligand
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A ligand may be any kind of ...
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of molecule, including another protein
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The transient nature of protein-ligand interactions is critical to ?
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life
- allowing an organism to respond rapidly and reversibly to changing environmental and metabolic circumstances |
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The interaction of a ligand binding to a site on a protein is
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- specific
- the protein can discriminate among the thousands of different molecules in its environment and selectly bind only one or a few |
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the protein in a protein-ligand can discriminate among ...
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the thousands of different molecules in its environment and selectly bind only one or a few
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A ligand binds at a site on the protein called ?
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the binding site
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A binding site of a protein is complementary to the ligand in
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size, shape, charge, and hydrophobic or hydrophilic character
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A given protein may have separate binding sites for
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- several different ligands.
- These specific molecular interactions are crucial in maintaining the high degree in a living system |
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Protein are flexible. Changes in conformation may be subtle, reflecting ...
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- molecular vibrations and small movements of animo acid residues throughout the protein.
- A protein flexing in this way is sometimes said to "breathe" |
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A protein flexing reflecting molecular vibs and small movements of animo acids is sometimes said to ?
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"breathe"
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Specific conformational changes are freq. essential to
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A protein's function
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The binding of a protein and ligand is often coupled to
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a conformational change in the protein that makes the binding site more complementary to the ligand, permitting tighter binding.
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The structural adaptation that occurs between protein and ligand is called
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induced fit
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Interactions between ligands and proteins may be regulated, usually through . .
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specific interactions with one or more ligands
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Enzymes represent a special case of ..
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protein function.
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Enzymes bind and chemically transform ...
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other molecules - they catalyze rxns.
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The molecules acted upon by enzymes are called ________ rather than ligands, and the ligand-binding site is called ___________
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- reaction substrates
- the catalytic site or active site |
