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21 Cards in this Set
- Front
- Back
Glycolysis
how many ATP go in |
2
|
|
Glycolysis
net gain |
2 NADH
2 ATP |
|
flouride inhibits which enzyme
|
enolase
|
|
the only reversible kinase in glycolysis
|
phosphoglycerate kinase
|
|
what poison inhibits glyceraldehyde-phosphate dehydrogenase
|
pentavalent arsenic
|
|
Malate aspartate shuttle
what receives the H+ from NADH |
OAA, converts it to malate
|
|
Malate aspartate shuttle
in the inner mitochondrial membrane, what does OAA get converted to and what molecule donates the amino group |
aspartate
glutamate |
|
the 5 cofactors of PDH
|
thiamine pyrophosphate (vit B1)
coenzyme A (CoASH) lipoic acid FAD NAD+ |
|
is PDH active or inactive when phosphorylated
|
inactive
PDH is active when dephosphorylated |
|
what makes wet beri-beri wet
|
edema
congestive heart failure due to starvation of energy |
|
Leighs disease
|
severe accumulation of lactic acid due to build up of pyruvate as a result of congenitally defective PDH complex
|
|
what does trivalent arsenic do
|
gobs up the disulfide swing arm of lipoic acid in PDH
|
|
3 things that allosterically stimulate PFK1
|
Fructose 2,6-bisphosphate
elevated [AMP] elevated [Pi] |
|
3 things that allosterically inhibit PFK1
|
elevated [ATP]
elevated [H+] elevated [citrate] |
|
inhibition of pyruvate kinase
|
elevated [ATP]
|
|
activation of pyruvate kinase
|
Fructose 1,6-bisphosphate
|
|
the enzyme that catalyzes the transfer of an amino group from glutamate to oxaloacetate in the malate/aspartate shuttle
|
aminotransferase
|
|
what keeps the malate/aspartate shuttle from running in reverse
|
cotransport of Glutamate into the mitochondrial matrix with H+
|
|
how does pyruvate get into the inner mitochondrial matrix
|
H+ symporter
since 4 H+ are required to make an ATP this is about I/4 of the cost of an ATP |
|
trivalent arsenic and Hg+ gob up the PDH lipoamide swing arm. What's the stuff that treats this?
|
British Anti-Lewisite
aka Dimercaprol |
|
beri-beri is a deficiency of
|
thiamine
|