Bio 2B03 Exam Review: Lecture 6

Front 1

Ligands of RTK pathway have the function of:

Back 1

Make cell proliferate and eventually differentiate

Front 2

Ligands of RTK activate:

Back 2

intrinsic kinase activity of transmembrane cell surface receptors

Front 3

Ligand binding of RTK does so by

Back 3

dimerization of receptor

Front 4

Phosphotyresines serve as

Back 4

docking sites for adapter proteins

Front 5

Adapter plus ___ couples RTKs to other components of signaling pathway

Back 5

Ras Protein

Front 6

Role of Adaptor proteins

Back 6

no enzymatic signaling activity, couple RTKs to other proteins in pathway, scaffold proteins

Front 7

3 types of adaptor proteins

Back 7

One SH2 domain (recognizes phosphorylated tyrosine, binds residue to C-Terminal) & two SH3 domains (recognizes Pro-rich sequences, binds SOS via SH3 domains

Front 8

Activation of GTP is accelerated by:

Back 8

Guanine exchange factor (GEF)

Front 9

Deactivation of G-Protein by

Back 9

GAP (GTPase Activating Protein) (NF1)

Front 10

What does MAP kinase Pathway accomplish

Back 10

Signal pass from Ras to protein Kinase cascade, activated by phosphorlation of Thr & Try residues

Front 11

What is the Map Kinase Cascade pathway? (steps)

Back 11

RTK -> Ras ->Raf -> MEK -> MAPK (Erk1 & Erk2)

Front 12

Ras activation leads to downsteam signaling known as

Back 12

MAPK cascade, which activates many transcription factors

Front 13

What does activation of MAPK Erk1 & Erk2 lead to?

Back 13

phosphorylation of Ternary complex factor (TCF) and Serum response factor (SRF)

Front 14

Adrenergic Receptor Pathway steps:

Back 14

Signal=catecholamines
Receptor=GPCR
Intracellular transduction=adenylyl cyclase
Second messanger=cAMP
Response=release of stored energy

Front 15

beta receptors are:

Back 15

stimulatory

Front 16

alpha2 receptors are

Back 16

inhibitory

Front 17

what activates the GPCR

Back 17

binding of hormone induces a conformational change in the receptor

Front 18

what does cAMP do?

Back 18

has different effects in different cell types mediated by regulating the activity of enzymes

Front 19

PKA is?

Back 19

cap-dependant protein kinases, causing a net affect of ATP