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20 Cards in this Set
- Front
- Back
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The signal recognition particle targets
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proteins to the rER.
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Describe the sequence of events between the transcription of an mRNA for a secreted protein and the arrival of that protein in the lumen of the endoplasmic reticulum.
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1. an initiation complex .
2. signal sequence, binds to an SRP 3. complex binds to the rER 4. the SRP then dissociates. 5. Chain elongation continues, crossing into the ER lumen 6. The signal sequence is cleaved. |
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Tuncamycin blocks
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he synthesis of oligosaccharides
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The NLS is found
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in the middle of a protein
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Put the following steps in the proper order with regard to protein synthesi
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1. The 50S initiation complex of the 30S subunit and mRNA.
2. Aminoacyl-tRNA binds to the A site. 3. Peptide bond formation shifts the growing peptide from the P to the A site. 4. Deacylated tRNA is released from ribosome. |
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Termination
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RF1
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Amino acid activation
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aminoacyl-tRNA
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Elongation
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EF-Tu
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Initiation
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Shine-Dalgarno sequence
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For the tRNA, the amino acid attaches to the
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3'-end
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The Shine-Dalgarno sequence is:
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upstream from the AUG sequence
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Puromyocin
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Causes premature termination of the protein synthesis
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Chloramphenicol
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Blocks peptidyl transfer in bacteria, mitochondria and chloroplasts
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Cyclohexamide
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Blocks peptidyl transfer in eukaryotes
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Tetracycline
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Blocks the A site on the bacterial ribosome
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Streptomycin
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Causes misreading of genetic code in bacteria
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How many different codon combinations actually code for an amino acid?
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61
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Which of the following would cause a frame shift mutation
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1 The removal of a base pair in the middle of the coding part of the gene
2 adding two base pairs to the coding part of a gene 3 Adding a base pair to the coding part of a gene |
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In Sickle-Cell Anemia, which is the most likely single base change that took place to cause the switch from a Glu to a Val?
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A-->T
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How many diffent mRNA sequences can specify the sequence Leu-Met-Tyr
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12
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