Bbc: Pharm Ch 1

Front 1

What does it mean if a drug is easily displaced from albumin?

Back 1

- it will have more of an effect than what was orginally thought b/c when a drug is bound to albumin it isn't active but when it is free it is active = overdose sx.

Front 2

Does Albumin bind to hydrophobic or hydrophilic drugs?

Back 2

Hydrophobic

Front 3

What does it mean if a drug induces P450?

Back 3

it increases the rate of metabolism of anything that is metabolised by P450
- the end result is less pharmacologically active drug

Front 4

What reactive with P450 would cause more drug to be active in the body than expected?

Back 4

- if the drug inhibited P450 it would dec the metabolism and more would be available in the body

Front 5

What are the drugs that can easily be removed from the albumin? Serum Proteins Can Spew.

Back 5

Serum Proteins Can Spew:

S - Sulfonamides
P - Phenylbutazone
C - Coumadin
S - Sulfonylureas

These drugs tend to be more active with polypharm.

Front 6

What are some examples of drugs that induce P450? One Pharmaceutical Brings About Rapid Liver Metabolism.

Back 6

- Drives the P450 to metabolism drugs more quickly, may find less in the blood.

One Pharmaceutical Brings About Rapid Liver Metabolism.

O - OCP (Oral Contraceptives)
P - Phenytoin
B - Barbiturates
A - Alcohol
R - Rifampin
L - Levodopa
M - Methadone

Front 7

What are some drugs that inhibit P450s? Some Pharmaceutical Classes Inhibit Drug Catabolism.

Back 7

- Inhibiting P450s, so more of the drug would be available in the body

Some Pharmaceutical Classes Inhibit Drug Catabolism.

S - Sulfonamides
P - Phentylbutazone
C - Chloramphenicol
I - Isoniazid
D - Dicumarol
C - Cimetidine

Front 8

What are some drugs that compete with Renal Transporters? Some Pharmaceuticals Plus Urate Stop Transporters.

Back 8

Some Pharmaceuticals Plus Urate Stop Transporters.

S - Sulfonamides
P - Probenecid
P - Penicillin
U - Urate (uric acid)
S - Salicylates
T - Thiazides