Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
15 Cards in this Set
- Front
- Back
cholinesterase inhibitors (reverse inhibitors)
|
used for moderate duration and treats myasenthia gravis, alzheimers, and parkinson's
|
|
cholinesterase inhibitors (irreversible inhibitors)
|
echothiophate (Phospholine Iodide) used for long duration and treats glaucoma
pralidoxime (2-PAM) is used to reverse the effect of echothiophate |
|
cholinesterase inhibitor
|
prototype: neostigmine (Prostigmin)
|
|
ambenonium (Mytealase)
|
cholinesterase inhibitor
|
|
pyridostigmine (Mestinon)
|
cholinesterase inhibitor
|
|
edrophomium (Tensilon)
|
cholinesterase inhibitor
|
|
cholinesterase inhibitor MOA
|
inhibits cholineserase form inactivating acetylcholine, thereby increasing amount of Ach available at receptor sites
|
|
neostigmine uses
|
treats myasenthia gravis, reversal of nondepolarizing neuromuscular blocking agents
|
|
ambenonium
|
treatment of myasenthia gravis
|
|
pyridostigmine
|
treatment of myasenthia gravis, reversal of nondepolarizing neuromuscular blocking agents
|
|
edrophonium
|
diagnosis of myasenthia gravis
reversal of ND neuromuscular blocking agents |
|
cholineserase inhibitors adverse
|
excessive muscarine stimulation as evidenced by increased GI motility, secretions
bradycardia, and urinary urgency adverse effects may be treated with atropine cholinergic crisis- can be treated with atropine provide ventilary support |
|
cholinesterase inhibitors contraindications
|
obstruction of GI and renal
caution in seizure disorders, hyperthyroidism, PUD, asthma, bradycardia, hypotension |
|
cholinesterase inhibitors interactions
|
atropine counteracts neostigmine
neostigmine reverses neuromuscular blockade caused by neuromuscular blocking agents after surgical procedures of overdose succinylcholine- avoid concurrent use |
|
cholinesterase inhibitor effectiveness
|
fewer episodes of fatigue
improvement in strength of chewing, swallowing, and performing ADLs |