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9 Cards in this Set
- Front
- Back
etiology of asthma
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mucus plug, edema, bronchoconstriction, cellular infiltration
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cardinal feature of most athmatics
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non specific bronchial hyperreactivity
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mechanism of beta agonist in bronchodilation
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activate adenylate cyclase => elevate cAMP levels
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mechanism of theophylline
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- phosphodiesterase inhibitor
- adenosine antagonist |
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ipratropium mechanism of action
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antimuscarinic => bronchodilation
antimuscarinic and b2 agonist are equal in COPD patient, but b2>antimuscarinics for asthma |
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cromolyn
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- poorly absorbed across mucosal membranes
- prevent late asthmatic response to inhaled allergen - does not affect cAMP - inhibit mast cell release in response to non-specific stimuli.. acts directly on mast cell membranes |
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mechanism of corticosteroids (beclamethasone)
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- no direct bronchodilator effect
- affect secretion of mediators and inflammatory component |
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zileuton
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inhibits leukotriene formation by inhibiting 5-lipoxygenase
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zafirlukast
montelukast |
block binding of LTD4 to its receptors
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