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26 Cards in this Set
- Front
- Back
What is the first line therapy for GAD? Why?
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SSRIs. Nearly as effective as benzodiazepines without the side effects.
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What is the mode of action of Buspirone?
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Partial 5HT1A agontist
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What is the advantage of using Buspirone?
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Effective as monotherapy, faster onset than SSRI, SNRI ADs. It is well tolerated with no abuse potential. Few side effects
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What is one distinct advantage of BZDs over ADs?
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Effective in acute panic attack due to rapid onset.
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What are the disadvantages of BZDs?
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High potential for abuse, potentially fatal with other CNS depressants (alcohol), adverse effects (sedation, ataxia, amnesia, etc)
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What would you use to treat GAD with panic? What would you not want to treat it with and why?
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BZDs. ADs, because they will actually increase the anxiety symptoms for the first couple of weeks.
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What do BZDs do to sleep stages?
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Decrease REM and SWS, increase stage 2 NREM sleep
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What is Triazolam and what is it used for?
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BZD, insomnia
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What is Estazolam and what is is it used for?
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BZD, insomnia
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What is Temazepam and what is is it used for?
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BZD, insomnia
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What is diazepam and what is it used for?
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BZD, anxiety
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What is Chlordiazapoxide and what is it used for?
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BZD, anxiety
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What is Alprazolam and what is it used for?
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BZD, anxiety
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What is Clorazepate and what is it used for?
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BZD, anxiety
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What is Medazolam and what is it used for?
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BZD, preprocedural drug ('Doc, I don't wanna remember anything!')
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What is Lorazepam and what is it used for?
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BZD, preprocedural drug ('Doc, I don't wanna remember anything!')
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What is Flumazenil and what is it used for?
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BZD binding site agonist for reversal of therapeutic effect or BZD OD, or post-procedural.
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Why do Non-BZDs (the Z-drugs) not have the same effects as BZDs?
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Act at BZD site, but are a1 selective, do not act as much at a2 and a3 receptors
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What is the advantage of using the Z-drugs over BZDs for insomnia?
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No disruption of sleep architecture and no REM rebound.
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What is Zolpidem and what is it used for?
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Z-Drug, insomnia
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What is Zaleplon and what is it used for?
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Z-Drug, insomnia
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What is Eszopiclone and what is it used for?
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Z-Drug, insomnia
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Why is Eszopiclone a special Z-drug?
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Approved for chronic use
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Why is Zaleplon a special Z-drug?
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Can take 4 hours before anticipated waking
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What is Ramelteon and what is it used for?
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Melatonin 1 Receptor agonist.
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What is the advantage of ramelteon?
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Very safe, no rebound, no tolerance, great for circadian desynchrony
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