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23 Cards in this Set
- Front
- Back
What are the anti-inflammatory agents? |
1. Glucocorticoids 2. Non-steroidal anti inflammatory drugs (NSAIDs) |
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What are three major actions of NSAIDs? |
1. Anti-inflammatory action 2. Analgesic effect 3. Antipyretic effect |
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Anti-inflammatory action |
1. Vasodilator prostaglandin (PGE2) decrease 2. Resulting to less oedema |
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Analgesic effect
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1. Decreased prostaglandin generation 2. Less sensation of nociceptive nerve endings to inflammatory mediators. |
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Antipyretic effect |
1. Decreased mediator prostaglanding that is responsible for elevating the hypothalamic set-point of temperature control. |
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What are the clinical use of NSAIDs |
Rheumatoid arthritis Gout To lower temperature |
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What are the unwanted effects of NSAIDs |
Inhibition of housekeeping enzyme (COX1) Nausea Vomit Gastric Skin reaction Liver disorders |
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What aspirin cause |
Irreversible inactivation of COX1 and COX2 Inhibit platelet aggregation |
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Aspirin metabolize in |
Liver |
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Unwanted effect of aspirin |
Gastric bleeding Dizziness Deafness (large dose) |
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Paracetamol commonly used as |
Non-narcotic analgesic-antipyretic agent |
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Paracetamol is selective inhibitor of |
COX3 |
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Toxic dose of paracetamol causing the drug to |
Converted by mixed function oxidase to N-acetyl-p-benzoquinone imine and react with proteins and kill the cell |
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What is the used of Anti-histamine |
for allergic reactions including allergic rhinitis,urticarial, insect bites and drug hypersensitives. |
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What is anti-emetics |
Prevention of motion sickness or other causes of nausea |
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What is the action of immunosuppressant drugs?
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Most act in the induction phase of immunological response, reducing lymphocyte proliferation (rapid increase in number) Some inhibit aspects of the effector phase of white blood cell. |
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Agent that inhibit Interleukin 2 (IL-2) production or action? |
Ciclosporin |
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Agent that inhibit cytokine gene expression |
Corticosteroids |
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Agent that inhibit purine and pyrimidine synthesis |
Azathioprine |
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Agent that block the T- cell surface molecule involve in signaling |
Monoclonal antibodies |
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What are the clinical use of immunosuppressant drugs? |
To suppress rejection of transplanted organs and tissue TO suppress graft versus host diseases in bone marrow transplant TO treat a variety of conditions with auto immune component in their pathogenesis |
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Arachidonate metabolites are |
Eicosanoids |
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Outline the action of anti inflammatory drugs |
1. Glucocorticoids inhibit transcription of the gene for COX2. |