In the context of the present study MLCP is of special interest. The endothelial MLCP is a heterotrimeric enzyme composed of a catalytic subunit, PP1, a regulatory myosin phosphatase targeting subunit
(MYPT1), and a 20-kDa subunit of yet unknown function.5,6 In smooth muscle cells, it is well established that the activity of MLCP is controlled …show more content…
by Rho kinase (Rock), which phosphorylates MYPT1 at its inhibitory sites,7 and the endogenous inhibitor of PP1, CPI-17 (PKC-potentiated inhibitory protein for PP1 of 17 kDa).8,9 However, in endothelial cells, the regulation of MLCP is not completely