We hypothesized that there are common gene pathways responsible for the schizophrenia–type 2 diabetes mellitus association in drug-naive subjects. In particular, wepropose that the insulin growth factor 2 m-RNA binding protein 2 (IGF2BP2) genetic variants rs4402960 and rs1470579 .associates and replicated in type 2 diabetes mellitus Egyptians (14,15) gene pathways maycontribute to both type 2 diabetes mellitus and schizophrenia Through this exploration , we tried to link thepathogenetic association between the two diseases at the molecular leve. Our hypothesis is innovative as, to our knowledge, to date thereare no data in the literature regarding genetic screening drug nave first episode schizophrenia patients for ,specific SNPs (IGF2BP2
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etes and prediction of future disease in diabetic Egyptian patients.( 14) and these findings were replicated in type 2 diabetes mellitus Egyptians (15) We postulated the causality hypothesis as having …show more content…
Blood samples were taken from healthy subjects without psychiatric, neurological or somatic disordersand history of head injuries, allergy and lipid or carbohydrate metabolism disorders, untreated with drugs. Healthy subjects did not use addictive substances and, , lived in similar socio-economic conditions. Subjects with significant medical illness or first degree family history of type 1 or type 2 diabetes mellitus were excluded. The healthy subjects are matched for age, gender and body mass index. Wit the schizophrenia patients The study was approved by the local Ethical and scientific committee, and written informed consent was obtained from all subjects or care givers after complete description of the study. Patients and healthy subjects underwent the same laboratory testing procedures
Procedure. All patients were clinically examined, individually interviewed, and diagnosed by a senior psychiatrist. The required data were then collected using specially prepared forms for the study. In order to obtain an objective history of the patients, accompanying close relatives were
etes and prediction of future disease in diabetic Egyptian patients.( 14) and these findings were replicated in type 2 diabetes mellitus Egyptians (15) We postulated the causality hypothesis as having …show more content…
Blood samples were taken from healthy subjects without psychiatric, neurological or somatic disordersand history of head injuries, allergy and lipid or carbohydrate metabolism disorders, untreated with drugs. Healthy subjects did not use addictive substances and, , lived in similar socio-economic conditions. Subjects with significant medical illness or first degree family history of type 1 or type 2 diabetes mellitus were excluded. The healthy subjects are matched for age, gender and body mass index. Wit the schizophrenia patients The study was approved by the local Ethical and scientific committee, and written informed consent was obtained from all subjects or care givers after complete description of the study. Patients and healthy subjects underwent the same laboratory testing procedures
Procedure. All patients were clinically examined, individually interviewed, and diagnosed by a senior psychiatrist. The required data were then collected using specially prepared forms for the study. In order to obtain an objective history of the patients, accompanying close relatives were