Bupropion is a unique antidepressant when chemically compared to tricyclic, tetracyclic, selective serotonin re-uptake inhibitor, or many other antidepressant drugs. Norepinephrine and dopamine are weakly inhibited by bupropion, but serotonin is not inhibited hence the name dopamine/norepinephrine reuptake inhibitor. Although the exact action of this drug is not fully understood, it appears to have the greatest impact on dopamine. Nicotine withdrawal symptoms are lessened by the increase in norepinephrine. Increase availability of dopamine at the synapse reduces craving for nicotine and also decreases the desire to smoke (Wishart, et al., 2008;2007).
Other indications of bupropion include ADHD, weight loss (BMI>30 kg/m2), bipolar, major depressive
Other indications of bupropion include ADHD, weight loss (BMI>30 kg/m2), bipolar, major depressive