Substance-Induced Mood Disorder: A Case Study

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DSM IV diagnosis for Margaret: Fluoxetine Hydrochloride-Induced Mood Disorder, With Mixed Features (APA, 1994).

Rationale: Substance-Induced Mood Disorder is distinguished from a primary Mood Disorder by taking into consideration the onset, course, and factors like drug abuse, substance intoxication and withdrawal. The Mixed Features show both symptoms of mania and depression, but neither predominates (APA, 1994).

Norepinephrine (NE) - norepinephrine help in regulation if anxiety and mood (Wasserman, 2011).
Dopamine (DA) - regulates attention, motivation, motor action, and mental activity (Wasserman, 2011).
Serotonin (5-HT) - affects our body temperature, sleep regulation, alertness, impulse control, and mood regulation (Wasserman, 2011).
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Since Margaret has been feeling more depressed, she doubled her dose of Flouxetine without consulting her doctor. Because of this, I assumed that it was the cause of her mania since it was stated in MIMS (2014) that one of the adverse effect of the drug is mania.
Other possible biological causes of mania: can be genes that one's inherit mother's health during pregnancy exposure to environmental stressors during infancy and childhood impairment in amygdala and prefontal cortex of the brain
 imbalances in levels of neurotransmitters such as dopamine, serotonin and norepinephrine
 substance abuse (cocaine & amphethamines)
 infectious diseases (influenza, encephalitis, Q fever, neurosyphyllis, general paresis)
 endocrine relations (hyperthyroidism)
 vitamin B12 deficiency
 rheumatological disease (rheumatic chorea, systemic lupus, erythematosus, diencephalic and third venticular tumors)
(Haycock, 2013; Curtin University School of Nursing & Midwifery,
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 Dry mouth (MIMS, 2014) - is an anticholinergic effect of antipsychotic drug related to blockage of cholinergic receptors (Heslop & Czarniak, 2013).
 Setraline side effects:
 Hyponatraemia (MIMS, 2014) - is a decreased sodium levels in the blood and treatment with sertraline appears to be the result of a syndrome of inappropriate antidiuretic hormone secretion (SIADH) (MIMS, 2014).
 Yawning (MIMS, 2014) - the side effect is not a result of poor sleep or fatigue, but the effect of SSRI on the hypothalamus (Sadock & Sadock, 2007).
 Fluvoxamine side effects:
 Constipation (MIMS, 2014). - due to the anticholinergic effect of the drug, it blocks cholinergic receptors that causes constipation (Heslop & Czarniak,

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