The reduction of this ketone produces secondary alcohols. Sodium borohydride is often used in this process because it reacts more rapidly with the carbonyl group than with the solvent. In this experiment, the reduction of 9-fluorenone using sodium borohydride to give 9-fluorenol will be examined. This reaction involves the transfer of a hydride ion from borohydride ion to the electrophilic carbonyl carbon with the accompanying transfer of the electron deficient boron atom to the carbonyl oxygen.1 The reaction is shown below: 10 is 9-fluorenone, 11 is the intermediate borate salt, and 12 is 9-fluorenol.…
In Experiment 12B we used an umpolung reagent in an umpolung synthesis to synthesize benzoin from benzaldehyde. Umpolung synthesis is a synthetic approach that allows us to switch the identity of a reacting species. For example, the normal chemical reactivity of a nucleophile can be switched to one of an electrophilic compound. Two common agents are cyanide and thiamine (Vitamin B). The mechanisms for both agents are the same.…
Henrietta Lacks was feeling sick 1952, she visited john Hopkins hospital for medical test. Doctors found out that she was suffering from cervical cancer. At that time a doctor name George Gey was working at the hospital, him and his colleagues were working in the lab trying to grow the first immortal human cell that could live outside the body and multiplies over time but they have been failing for years. While Henrietta was at the hospital some of her cells were taken without a consent and her tissue was going to change things when Mary, Gey assistant found out that Henrietta cell multiplied and she named it HeLa. The name HeLa comes from the first two initial of Henrietta Lacks first and last name.…
Experiment 7 Electrophilic Aromatic Substitution Of Salicyamide Name: Lidia Santiana Palha Student number: s3333523 Email-address: lidiapalha@gmail.com Name of demonstrator: H.Helbert Reaction Equation Summary Salicylamide and sodium iodide are dissolved in ethanol, and stirred and cooled to 0. After that household bleach was added while stirring vigorously, solution changed from colorless to pale yellow. Sodium thiosulphate and hydrochloric acid were added aswell.…
The cyclohexene product was converted, into trans-1,2-dibromocyclohexane through bromination resulting…
Nucleophilic Substitution: Preparation of 1-Bromobutane and Alkyl Halide Classification Tests INTRODUCTION The purpose of this experiment was to demonstrate the conversion of a primary alcohol to 1-bromobutance with the Sn2 mechanism using sodium bromide and then to characterize the compound with two different alkyl halide tests. DISCUSSION AND CONCLUSION Nucleophilic aliphatic substitution involves chemical reactions where a neutral molecule or an anion called a nucleophile substitutes a leaving group by attacking an electrophilic, Lewis acidic carbon atom. Leaving groups are molecular compounds that are departed and replaced by the nucleophile. This interconversion is commonly known as the attack of the nucleophile.…
Consequently, the base attacks a hydrogen on the least substituted carbon (primary carbon). In this case, steric hindrance is reduced and the elimination reaction is faster, so a less substituted alkene is more favored, and becomes the major product. 2-Bromoheptane + Sodium Methoxide. The 2-Bromoheptane + Potassium TertButoxide reaction yielded 4 different products: 1-heptene,…
The instructor checked the apparatus and then put in 8 mL of anhydrous ether. The 4.5 mL of bromobenzene was added to the flask to make the Grignard reagent. The instructor added 12 mL of ether after the reaction changed colors clear to dark brown. The reaction was left to react for 30 minutes. During this time, 2.3 mL of methyl benzoate was obtained in a graduated cylinder and…
Purpose: The purpose of this laboratory was to synthesize isopentyl acetate, commonly known as banana oil, in a reaction of methanol and isopentyl alcohol catalyzed by sulfuric acid. Through this Fischer esterification reaction, it was possible to learn about using a Reflux condenser to run a reaction as well as purifying the product through various washes and extractions along with simple distillation. In addition, the product of the experiment was carefully analyzed based upon boiling point, physical characteristics, IR and 1H NMR. The overall objective was to successfully isolate the product of isopentyl acetate and observe the purity of this product.…
Furosemide is a medication known as a loop diuretic (Allen, 2013). A diuretic is a medication which increases the amount of urine that passes out from the kidneys and they are often referred to as water tablets. It works by eliminating water and salt from the body through urination. In the kidneys, salt and water are filtered out of the blood and into the tubules of the kidney to the Glomerulus (Waugh and Grant, 2014), making the filtered fluid into urine (Omudhome, 2014). The sodium, chloride and water that are filtered out of the blood is then reabsorbed back into the blood before being eliminated as urine (Omudhome, 2014).…
The polar protic solvents of an SN1 reaction tend to be the nucleophile that attacks the carbocation. The SN1 reaction scheme and mechanism of 2-chloro-2-methylbutane from 2-methyl-2-butanol is indicated in Figure 1 shown below.…
This the reaction involves a tertiary alkyl halide, which is tert-butyl chloride, which further indicates that the reaction follows a SN1…
The sodium bromide reacts with the sulfuric acid to produce hydrobromic acid, which will then react with n-butyl bromide to produce n-butyl alcohol via an SN2 reaction. Sulfuric acid also serves as an excess reagent to shift equilibrium…
A mixture of 5.0 mL concentrated nitric acid and 5.0 mL concentrated sulfuric acid was prepared in a 100-mL Erlenmeyer flask and was placed into a water bath to cool to room temperature. 3.93 grams of bromobenzene was added to the solution over a period of 10 minutes with constant mixing. After all of the bromobenzene is added, the mixture was heated with a hot water bath for 30 minutes. The flask was cooled to room temperature and then poured into 50 mL of ice-cold water in a 200 mL beaker. The crude product was isolated by vacuum filtration and then washed with cold water.…
Plastic surgery to alter physical features of a child It is often say that having a child changes everything, but having a child with a birth defect brings even greater challenge. There is a lot of controversy between those who think that surgery can improve the physical functioning, social appearance, and acceptance to those individuals with some type of handicap and those who don’t. However, “parents should consider Plastic surgery to correct defects of the face, skull, and neck which is reconstructive in nature, not cosmetic, as some insurance companies assert," said Steven Buchman, MD, ASPS Member Surgeon and author of the report.…