Renal denervation involves application of radiofrequency waves to ablate renal nerves in order to reduce RSNA1*. The catheter is taken to the kidney via the femoral artery. There have been many different techniques and methods of ablating renal sympathetic nerves, with the simplicity trial proving to be the most effective and efficient4.
During the symplicity HTN-1 trails, 153 patients over 19 different site around the world received renal sympathetic using the symplicity catheter2. The symplicity catheter is rotated around the renal artery, 4-6 ablations are made at different sites. The results are summarised in table 1. Individual results showed a significant reduction in Blood pressure (p<0.0001)2.
Symplicity HTN-2 trials were performed …show more content…
There were no adverse effects in either of the trials that required the patient to be treated2,3, thus this treatment is relatively safe. Catheter-based renal denervation was successful in controlling resistant hypertension for at least two years2.
The simplicity Catheter by medtronic is the most successful catheter thus far. Many companies have developed catheter of different size that denervated nerves using radiofrequency4. ReCor Medical have developed a catheter ‘paradise’ which use ultrasound instead of radiofrequency to ablate nerves4. Using this technique the developers were able to reduce systolic blood pressure by 33 mmHg reported after six month follow up period4.
There are surgical options for treating hypertension, such as splanchnicectomy5, ganglionectomy5 or sympathectomy6. Splanchnicectomy involves surgical removal of splanchnic nerves similarly ganglionectomy involves removal of ganglion. These surgeries carry a high level of risk. Intraspinal rhizotomy, involving the removal of six dorsal/nerves, this procedure is successful in lowering blood pressure however, it has a high morbidity rate with many patients left paralyzed due to the disturbance of motor fibers6. Modification to this previously mentioned surgery were made and extraspinal resection was adopted involving splanchnics and parts of paravertebral ganglia6. This surgery yielded
During the symplicity HTN-1 trails, 153 patients over 19 different site around the world received renal sympathetic using the symplicity catheter2. The symplicity catheter is rotated around the renal artery, 4-6 ablations are made at different sites. The results are summarised in table 1. Individual results showed a significant reduction in Blood pressure (p<0.0001)2.
Symplicity HTN-2 trials were performed …show more content…
There were no adverse effects in either of the trials that required the patient to be treated2,3, thus this treatment is relatively safe. Catheter-based renal denervation was successful in controlling resistant hypertension for at least two years2.
The simplicity Catheter by medtronic is the most successful catheter thus far. Many companies have developed catheter of different size that denervated nerves using radiofrequency4. ReCor Medical have developed a catheter ‘paradise’ which use ultrasound instead of radiofrequency to ablate nerves4. Using this technique the developers were able to reduce systolic blood pressure by 33 mmHg reported after six month follow up period4.
There are surgical options for treating hypertension, such as splanchnicectomy5, ganglionectomy5 or sympathectomy6. Splanchnicectomy involves surgical removal of splanchnic nerves similarly ganglionectomy involves removal of ganglion. These surgeries carry a high level of risk. Intraspinal rhizotomy, involving the removal of six dorsal/nerves, this procedure is successful in lowering blood pressure however, it has a high morbidity rate with many patients left paralyzed due to the disturbance of motor fibers6. Modification to this previously mentioned surgery were made and extraspinal resection was adopted involving splanchnics and parts of paravertebral ganglia6. This surgery yielded