Another factor that may influence prolactinomas evolution is their natural history. Koppelman et al studied 25 women with untreated hyperprolatinemia for a mean period of 11.3 years. Seven of 22 patients with amnorreia resumed menses spontaneously. Galacthorrea resolved completely in 8 of 19. At the reevaluation, mean PRL levels decrease from 225 µg/L, to 155 µg /L. One patient had a slight progression of sellar abnormality. (G) Sisam et al (H) found that nearly 55% of 38 patients with untreated microprolactinomas had normalization of prolactine levels and there was no tumor regrowth during a mean follow-up of 31 months. Jeffcoate et al (F) following women with hyperprolactinemia (macroprolactinomas excluded) for 15 years, found that 33% of
