Polycystic Ovary Syndrome Essay

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Polycystic ovary syndrome (PCOS) affects up to 10% of women in the reproductive age (1). PCOS is a proinflammatory state characterized by menstrual dysfunction and hyperandrogenism and is associated with features of the metabolic syndrome, particularly, obesity, diabetes, dyslipidemia, and atherosclerosis
(1– 4).
The metabolic syndrome is associated with excessive accumulation of central body fat. Adipose tissue (AT) produces several cytokines termed adipokines, which have
ISSN Print 0021-972X ISSN Online 1945-7197
Printed in U.S.A.
Copyright © 2013 by The Endocrine Society
Received May 13, 2013. Accepted October 9, 2013.
First Published Online October 23, 2013
Abbreviations: AT, adipose tissue; BMI, body mass index; CTRP3, C1q complement/TNFrelated …show more content…
JCEM ONLINE
Hot Topics in Translational Endocrinology—Endocrine Research doi: 10.1210/jc.2013-2227 J Clin Endocrinol Metab, December 2013, 98(12):E1891–E1900 jcem.endojournals.org E1891
The Endocrine Society. Downloaded from press.endocrine.org by [${individualUser.displayName}] on 15 July 2016. at 15:19 For personal use only. No other uses without permission. . All rights reserved. widespread effects, pivotal in the pathogenesis of insulin resistance, diabetes, and atherosclerosis (5). Furthermore, the accumulation of visceral AT poses a higher cardiometabolic risk than sc AT (6) because elimination of visceral rather than sc AT has been shown to promote insulin sensitivity (7). The link between inflammation and insulin resistance in obesity and diabetes has been well

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