Pharmacodynamics
Pharmacodynamics refers to the mechanisms of drug action. Loratadine is a “non-sedating” tricyclic anti-histamine that possesses competitive, selective, peripheral H1-receptor antagonistic activity. The onset of the anti-histaminic effect occurs 1-2 hours after the administration of the drug and the peak effect occurs between 8-12 hours. Loratadine is known as a long-acting anti-histamine as its anti-histaminic effect can persist for up to 24 hours. Histamine is produced from the amino acid histidine and is found in high concentrations within the vesicles of mast cells, enterochromaffin cells in the gut and in some neurons. Histamine is metabolized by Monoamine and Diamine oxidase and is released from mast cells during IgE-mediated
Pharmacodynamics refers to the mechanisms of drug action. Loratadine is a “non-sedating” tricyclic anti-histamine that possesses competitive, selective, peripheral H1-receptor antagonistic activity. The onset of the anti-histaminic effect occurs 1-2 hours after the administration of the drug and the peak effect occurs between 8-12 hours. Loratadine is known as a long-acting anti-histamine as its anti-histaminic effect can persist for up to 24 hours. Histamine is produced from the amino acid histidine and is found in high concentrations within the vesicles of mast cells, enterochromaffin cells in the gut and in some neurons. Histamine is metabolized by Monoamine and Diamine oxidase and is released from mast cells during IgE-mediated