INTRODUCTION:
Pharmaceutical field is the research and development intensive field. The search for safe and effective drugs continues to be major efforts for all the pharmaceutical industries. There are enormous complexities for discovering and testing new drugs because of the many aspects of safety, efficacy and economics which determines the acceptability of a drug. Nose is one of the delicate organs of the human body, as a result of which nasal drug delivery is challenge for formulator. Intranasal drug delivery is now recognized to be a useful and reliable alternative to oral and parenteral routes. One of the major benefits for nasal drug delivery is self medication, along with faster and higher drug absorption achievement. Hussain et al has described regarding the nasal absorption of propranolol in rats was equivalent to intravenous route [1]. This work had showed the path highlighting the importance and seriousness for systemic drug delivery through nasal route.
The other advantages can for drug administration through …show more content…
Tetrahydrozoline is an alpha agonist and acts by constriction of blood vessels. Jones DG et al, have clearly identified and reported that it resulted symptomatic sinoatrial node arrest because of ingestion by a 16 year boy of quantity less than 15 ml of 0.05% tetrahydrozoline [39]. Matthew E. Stillwell et al, have described that tetrahydrozoline can cause central nervous system (CNS) depression when it is consumed orally. Some time before, it was reported that tetrahydrozoline used in combination of alcohol for intoxication of probable victims exposing them more fragile to sexual assaults [40, 41]. Emanuel Chusid et al, have highlighted regarding nasal instillation of tetrahydrozoline nasal drops in 10 week old boy led to severe respiratory depression along with pharmacology and toxicology of the drug
Pharmaceutical field is the research and development intensive field. The search for safe and effective drugs continues to be major efforts for all the pharmaceutical industries. There are enormous complexities for discovering and testing new drugs because of the many aspects of safety, efficacy and economics which determines the acceptability of a drug. Nose is one of the delicate organs of the human body, as a result of which nasal drug delivery is challenge for formulator. Intranasal drug delivery is now recognized to be a useful and reliable alternative to oral and parenteral routes. One of the major benefits for nasal drug delivery is self medication, along with faster and higher drug absorption achievement. Hussain et al has described regarding the nasal absorption of propranolol in rats was equivalent to intravenous route [1]. This work had showed the path highlighting the importance and seriousness for systemic drug delivery through nasal route.
The other advantages can for drug administration through …show more content…
Tetrahydrozoline is an alpha agonist and acts by constriction of blood vessels. Jones DG et al, have clearly identified and reported that it resulted symptomatic sinoatrial node arrest because of ingestion by a 16 year boy of quantity less than 15 ml of 0.05% tetrahydrozoline [39]. Matthew E. Stillwell et al, have described that tetrahydrozoline can cause central nervous system (CNS) depression when it is consumed orally. Some time before, it was reported that tetrahydrozoline used in combination of alcohol for intoxication of probable victims exposing them more fragile to sexual assaults [40, 41]. Emanuel Chusid et al, have highlighted regarding nasal instillation of tetrahydrozoline nasal drops in 10 week old boy led to severe respiratory depression along with pharmacology and toxicology of the drug