NSC 210902 is an ATP competitive inhibitor of CK2 [1].
Casein Kinase 2 (CK2) is a protein kinase involved in the phosphorylation of various cellular proteins, which have been essential for cell growth and transcription, as well as the regulators of cell cycle and apoptosis. It has been reported that casein kinase 2 is activated following Wnt signaling pathway activation. Abnormal CK2 expression and function have been associated with a number of pathologies, including inflammatory, infectious, and carcinogenic processes. Overexpression of CK2 is associated with cell transformation and neoplasia [1]. NSC 210902 inhibited the activity of CK2 with an IC50 of 1 μM in an ATP-competitive manner. NSC 210902 competitively inhibited binding of
Casein Kinase 2 (CK2) is a protein kinase involved in the phosphorylation of various cellular proteins, which have been essential for cell growth and transcription, as well as the regulators of cell cycle and apoptosis. It has been reported that casein kinase 2 is activated following Wnt signaling pathway activation. Abnormal CK2 expression and function have been associated with a number of pathologies, including inflammatory, infectious, and carcinogenic processes. Overexpression of CK2 is associated with cell transformation and neoplasia [1]. NSC 210902 inhibited the activity of CK2 with an IC50 of 1 μM in an ATP-competitive manner. NSC 210902 competitively inhibited binding of