In Yao et al (2012), their retrospective cohort study was conducted to determine the efficacy of negative pressure wound therapy (NPWT) in comparison to non-NPWT patient in the real world. The cohort study was conducted in Boston Medical Centre. It gathered patient’s data that began from 2008 and monitored those patients for 8 years. The researchers performed data collection using electronic medical …show more content…
(2010), their pilot prospective study was conducted locally to evaluate the usefulness of vacuum assisted closure therapy or VAC in the healing process of chronic diabetic foot ulcers. The National University Hospital (NUH) Multi-Disciplinary Team for Diabetic Foots problems in Singapore conducted this cohort study. The keywords that were used in the search engine were diabetic foot wound, negative pressure dressing and wound healing. The study was conducted in 11 patients aged between 18 and 69 years old were seen in the Department of Orthopaedic Surgery of NUH. The included patients had ray amputation wounds, debridement wound due to necrotizing fasciitis, post-drainage wound, heel ulcer with exposed calcaneum and sole ulcer with exposed fascia (Nather et al. 2010). During the application of the VAC therapy the description, measurements and locations of the wounds were recorded. Significant histories, comorbidities and social aspects were also documented. Furthermore, before the application of VAC, all patients underwent radical debridement. Upon the application of the VAC, the negative pressure was commenced on a standard pressure of -125 mmHg, however if the patient experienced pain, the pressures were adjusted between -75 and -100 mmHg (Nather et al. 2010). Statistical analysis was done using a comparison between areas of wound before and after the application of VAC and also by using a t-test for statistical variances. Moreover, the test used in this …show more content…
The study was done on 30 patients, which was conducted in Dayanand Medical College and University. Terms used for the study were healing, negative pressure dressing and ulcer. It included patients aged 20 and 75 years of age, of both sexes with wound ulcer area between 50 and 200 cm2 and diagnostic criteria based on Diabetes Mellitus made by the American Diabetes Association. Meanwhile, it excluded patients aged less than 20 or more than 75 years of age, septicemia, osteomyelitis, malignant disease in a wound, venous insufficiency, patients taking immunosuppressive drugs, cardiovascular, pulmonary and immunological disease. It involved two groups, which were randomly divided- study group and control group (Nain et al. 2011). In the study group the patients received negative pressure dressing therapy with a range of -50 to -125 mmHG intermittently while the control group received moistened dressings twice a day. Nain et al. (2011) found that 75% of the patient showed an early granulation in the study group on 2nd week while in control group the appearance of granulation started on 2nd week with only 30%, 4th week was also 30% and 5th week was with 20%. Furthermore, there has been evidence that study group presented with a rapid clearance of bacterial loading as compared to control group (Nain et al.