Methamphetamine (METH) is a highly addictive psychostimulant drug and use has increased rapidly throughout the world. From the previous study, it has been shown that METH is directly neurotoxic and change of structure and function in brain. METH-induced glutamate overflow by action on N-methyl-D-aspartate (NMDA) receptor in the several brain areas for instance striatum, hippocampus, and cerebral cortex. These areas associated with the cognitive impairment in addict. Several studies reported that beneficial effects of melatonin (MEL) on cognitive decline in Alzheimer’s disease and in mild cognitive impairment patients. Accordance with in vivo results that MEL can relieve cognitive impairment and memory deficit, and reduction of protein about
