Factor 1 Essay

Dr. Paul Arnor Owren was an award-winning Norwegian physician, known for having discovered the Factor V, which is a protein that is essential for clotting. “The Factor V deficiency was first described in a Norwegian patient in 1943 and reported by Dr. Paul Owren in 1947. Its incidence is about 1 in 1 million; fewer than 200 cases have been documented worldwide. Before there was a Factor V, there was also a factor 1, 2, 3, and 4. The factor 1 is fibrinogen which is a glycoprotein in vertebrates that helps in the formation of blood clots. The factor 2 is prothrombin which is a vitamin K dependent proenzyme that functions in the blood coagulation system. The factor 3 is thrombokinase which is an enzyme liberated from blood platelets that converts prothrombin into thrombin as blood starts to clot. Lastly factor 4 is calcium. The Factor V deficiency is usually inherited, meaning both parents must carry the gene to pass it on to their children; it affects men and women equally. (National Hemophilia Foundation). The factor V deficiency also known as the Owerns disease, is a very rare blood clotting disorder that results in slow or prolonged blood clotting after an injury or surgery. …show more content…
Babies with severe Factor V deficiency are at increased risk of intracranial hemorrhage which is bleeding that occur in the skull, or bleeding in the brain. People with severe Factor V deficiency can also experience bleeding in the lungs and gastrointestinal tract, which can be life threatening. Women frequently have menorrhagia which is long, heavy periods” (National Hemophilia Foundation). Fresh plasma or fresh frozen plasma infusions are used to correct the deficiency temporarily and should be given daily during a bleeding episode. The loading dose of FFP is 15-20 mL/kg and then 3-6 mL/kg daily (E Medicine