Authors/citation Study purpose/ Research question Sample/ Participants Design Variables: Dependent Independent Procedures Analysis Results Recommendations Level of Evidence
Mukhopadhyay et al., 2010 This study has two purposes: The first purpose is to see whether a restrictive blood transfusion along with blood conservation system will decrease the amount of pack red blood cell transfusion. The second purpose is to see whether the blood conserving apparatus will conserve hemoglobin level from admission to discharge. Fore every single participant in the control group there are two intervention members. N=80 Participants in the control group and N=170 participants in the intervention group. The original numbers were 106 in the control, six patients were excluded due to active bleeding, 20 patients were admitted for less than 24hrs, and 7 patients died. In the active group, there were 231 participants, 5 patients had active bleeding, 56 patients were admitted to ICU for less than 24hrs, 18 patients died. All of the participants had arterial or central venous catheter line in place. Before and after study. Independent variables: Venous-arterial blood management system (VAMP) and strict transfusion protocol. Dependent variable: Preserved hemoglobin and prevention of transfusion. Following data were collected on admission, prior to discharge from the ICU or hospital, demographics, APACHE II score, prior PRBC transfusion, the need for renal replacement therapy, ICU length of stay (LOS), mortality and last hgb before the patient died. Linear regression model and two-sided sample t-test Significantly decreased transfusion requirement in the active group 0.068 vs 0.131 in the control group and preserved hemoglobin level in the intervention group 2.13 vs 1.44 in the control group. Restrictive blood transfusion and the blood-saving system works in order to prevent unnecessary blood loss. Level III Historical control trial. Riessen et al., 2015 The research question asks, will introducing a blood-saving bundle (BSB) decrease acute anemia in the high risk ventilated medical intensive care unit patients. Control group N=41 (617 observation day) participants and intervention BSB group N=50 (559) observation day. Before and after study Longitudinal. Independent variables: Blood-saving bundle (BSB) and transfusion restriction. Dependent variable: decreased diagnostic related blood loss. This study was performed on a 12 bed medical ICU at the university hospital. The control group was the before study from January to June of 2008. From July 2008 to March 2009 the intervention BSB protocol was implemented. Included in the BSB protocol was: a closed system blood saving apparatus, using smaller sample tubes, decreasing the frequency of blood draws and add a restrictive transfusion threshold of 7.5g/dl. Two sided sample t-test and fisher exact test and covariance analysis (ANCOVA). Mean hemoglobin level decreased from 43ML per ICU day to 15.0ML/ICU day after the implementation of …show more content…
Second: the need for transfusion in relation to the result of hemoglobin and hematocrit. Third: To check the effect it has on the arterial pressure monitoring waveforms. Fourth: To see if there is a change in the number of needle sticks. Total number of participants were 100 patients admitted to the Medical intensive care unit requiring arterial line monitoring. The control group received the normal pressure line monitoring N=50 and Active group with the venous arterial blood management system (VAMP) N=50. Exclusion criteria were active bleeding or chronic kidney disease on admission. Prospective Randomized Controlled Trial. Independent variable was using a venous, arterial blood management system (VAMP). Dependent variables: The effect of the device on the transfusion requirement, result of hemoglobin and hematocrit, change in the number of needle sticks and effect on arterial monitoring wave line. Study was done in the critical care unit of Northwestern Memorial Hospital. Patients were enrolled blindly into Either the control group or the active group "based on predetermined, random assignments contained in sealed, consecutively numbered envelopes" (p502). This was a 14 day study and the following data were gathered in both groups: "age, gender, discharge status, duration of ICU stay, time in the study, frequency and volume of the blood drawn for diagnostic testing; volume of blood discarded, every 12hrs hemoglobin and hematocrit (H&H) check" or mean H&H if it was stable the day before and no labs were drawn that day (p503). Two sample t-test and Chi-square test. Linear regression test to see the relation between hemoglobin and hematocrit. P (p506). Level II
Mukhopadhyay et al., 2010 This study has two purposes: The first purpose is to see whether a restrictive blood transfusion along with blood conservation system will decrease the amount of pack red blood cell transfusion. The second purpose is to see whether the blood conserving apparatus will conserve hemoglobin level from admission to discharge. Fore every single participant in the control group there are two intervention members. N=80 Participants in the control group and N=170 participants in the intervention group. The original numbers were 106 in the control, six patients were excluded due to active bleeding, 20 patients were admitted for less than 24hrs, and 7 patients died. In the active group, there were 231 participants, 5 patients had active bleeding, 56 patients were admitted to ICU for less than 24hrs, 18 patients died. All of the participants had arterial or central venous catheter line in place. Before and after study. Independent variables: Venous-arterial blood management system (VAMP) and strict transfusion protocol. Dependent variable: Preserved hemoglobin and prevention of transfusion. Following data were collected on admission, prior to discharge from the ICU or hospital, demographics, APACHE II score, prior PRBC transfusion, the need for renal replacement therapy, ICU length of stay (LOS), mortality and last hgb before the patient died. Linear regression model and two-sided sample t-test Significantly decreased transfusion requirement in the active group 0.068 vs 0.131 in the control group and preserved hemoglobin level in the intervention group 2.13 vs 1.44 in the control group. Restrictive blood transfusion and the blood-saving system works in order to prevent unnecessary blood loss. Level III Historical control trial. Riessen et al., 2015 The research question asks, will introducing a blood-saving bundle (BSB) decrease acute anemia in the high risk ventilated medical intensive care unit patients. Control group N=41 (617 observation day) participants and intervention BSB group N=50 (559) observation day. Before and after study Longitudinal. Independent variables: Blood-saving bundle (BSB) and transfusion restriction. Dependent variable: decreased diagnostic related blood loss. This study was performed on a 12 bed medical ICU at the university hospital. The control group was the before study from January to June of 2008. From July 2008 to March 2009 the intervention BSB protocol was implemented. Included in the BSB protocol was: a closed system blood saving apparatus, using smaller sample tubes, decreasing the frequency of blood draws and add a restrictive transfusion threshold of 7.5g/dl. Two sided sample t-test and fisher exact test and covariance analysis (ANCOVA). Mean hemoglobin level decreased from 43ML per ICU day to 15.0ML/ICU day after the implementation of …show more content…
Second: the need for transfusion in relation to the result of hemoglobin and hematocrit. Third: To check the effect it has on the arterial pressure monitoring waveforms. Fourth: To see if there is a change in the number of needle sticks. Total number of participants were 100 patients admitted to the Medical intensive care unit requiring arterial line monitoring. The control group received the normal pressure line monitoring N=50 and Active group with the venous arterial blood management system (VAMP) N=50. Exclusion criteria were active bleeding or chronic kidney disease on admission. Prospective Randomized Controlled Trial. Independent variable was using a venous, arterial blood management system (VAMP). Dependent variables: The effect of the device on the transfusion requirement, result of hemoglobin and hematocrit, change in the number of needle sticks and effect on arterial monitoring wave line. Study was done in the critical care unit of Northwestern Memorial Hospital. Patients were enrolled blindly into Either the control group or the active group "based on predetermined, random assignments contained in sealed, consecutively numbered envelopes" (p502). This was a 14 day study and the following data were gathered in both groups: "age, gender, discharge status, duration of ICU stay, time in the study, frequency and volume of the blood drawn for diagnostic testing; volume of blood discarded, every 12hrs hemoglobin and hematocrit (H&H) check" or mean H&H if it was stable the day before and no labs were drawn that day (p503). Two sample t-test and Chi-square test. Linear regression test to see the relation between hemoglobin and hematocrit. P (p506). Level II