Eighth, is the continued use of opioids in situations that it is physically hazardous. The ninth criteria includes the recurrent use of opioids despite the knowledge that the substance has caused physical or psychological problems. Tenth, is tolerance to the substance which is marked by a) an increased amount of opioids to in order to achieve the desired effects and b) the diminished effect with continued use of the same amount of the opioid. Lastly, the eleventh criteria is characterized by withdrawal, which is observed through a) the characteristic opioid withdrawal syndrome and b) the use of opioids or similar substances to relieve or avoid withdrawal symptoms. The presence of a characteristic opioid withdrawal syndrome is manifested as the a) discontinued or reduced use of opioids has been heavy and lasted for several weeks or longer and b) the presence of three or more of the following symptoms within minutes to several days of the discontinuation or reduction of opioid use: dysphoric mood, nausea or vomiting, muscle aches, rhinorrhea, sweating, diarrhea, yawning, fever, and
Eighth, is the continued use of opioids in situations that it is physically hazardous. The ninth criteria includes the recurrent use of opioids despite the knowledge that the substance has caused physical or psychological problems. Tenth, is tolerance to the substance which is marked by a) an increased amount of opioids to in order to achieve the desired effects and b) the diminished effect with continued use of the same amount of the opioid. Lastly, the eleventh criteria is characterized by withdrawal, which is observed through a) the characteristic opioid withdrawal syndrome and b) the use of opioids or similar substances to relieve or avoid withdrawal symptoms. The presence of a characteristic opioid withdrawal syndrome is manifested as the a) discontinued or reduced use of opioids has been heavy and lasted for several weeks or longer and b) the presence of three or more of the following symptoms within minutes to several days of the discontinuation or reduction of opioid use: dysphoric mood, nausea or vomiting, muscle aches, rhinorrhea, sweating, diarrhea, yawning, fever, and