Coronary artery disease (CAD) is a narrowing of the small blood vessels that supply blood and oxygen to the heart. Coronary artery disease (CAD) is the leading cause of death worldwide. While the symptoms and signs of coronary artery disease are noted in the advanced state of disease, most individuals with coronary artery disease show no evidence of disease for decades as the disease progresses before the first onset of symptoms, often a "sudden" heart attack, finally arises (Gaziano et al., 2011).
Heart failure was classically viewed as synonymous with left ventricular pump dysfunction, usually progressive, resulting in a common end-stage cardiac phenotype of dilation, thinned walls, and poor contractility. Heart failure may be caused by myocardial …show more content…
(2011) demonstrated for the first time that omentin plays an anti-inflammatory role by peventing the TNF-α-induced COX-2 expression in vascular endothelial cells. Sahgn et al. (2011) found that the plasma levels of omentin were decreased in patients with coronary artery disease (CAD), which indicated that omentin-1 may also be involved in the occurrence of coronary artery disease.
Kazama et al. (2012) found that omentin inhibits TNF-α-induced inflammation of intravascular Smooth Muscle Cells (SMCs), and its anti-inflammatory role is attributed, at least in part, to the inihbition of superoxide production. Omentin has two isoforms: omentin-1 and omentin-2; omentin-1 was shown to be the major circulating isoform in human plasma. In addition, omentin-1 was also regarded as a protective cytokine in the metabolic imbalance condition of the body. Wang et al. (2014) investigated the alteration of plasma levels of omentin-1 in elderly patients with coronary artery disease. They concluded that decreased levels of omentin-1 may be involved in the occurrence and development of coronary artery disease (CAD). Omentin-1 may be protective and pro-inflammatory cytokines. Additionally, omentin-1 may be related to lipid
Heart failure was classically viewed as synonymous with left ventricular pump dysfunction, usually progressive, resulting in a common end-stage cardiac phenotype of dilation, thinned walls, and poor contractility. Heart failure may be caused by myocardial …show more content…
(2011) demonstrated for the first time that omentin plays an anti-inflammatory role by peventing the TNF-α-induced COX-2 expression in vascular endothelial cells. Sahgn et al. (2011) found that the plasma levels of omentin were decreased in patients with coronary artery disease (CAD), which indicated that omentin-1 may also be involved in the occurrence of coronary artery disease.
Kazama et al. (2012) found that omentin inhibits TNF-α-induced inflammation of intravascular Smooth Muscle Cells (SMCs), and its anti-inflammatory role is attributed, at least in part, to the inihbition of superoxide production. Omentin has two isoforms: omentin-1 and omentin-2; omentin-1 was shown to be the major circulating isoform in human plasma. In addition, omentin-1 was also regarded as a protective cytokine in the metabolic imbalance condition of the body. Wang et al. (2014) investigated the alteration of plasma levels of omentin-1 in elderly patients with coronary artery disease. They concluded that decreased levels of omentin-1 may be involved in the occurrence and development of coronary artery disease (CAD). Omentin-1 may be protective and pro-inflammatory cytokines. Additionally, omentin-1 may be related to lipid