We found that airway ciliary beat frequency in aged C57BL/6 mice was lower than that of the young mice significantly ,and the transplantation of mitochondria derived from younger or older airway epithelial cells can significantly improve the airway cilia beat frequency in aged C57BL/6 mice.We also identified the mechanisms underlying the effects of transplanted mitochondria, which was associated with the mitochondrial dysfunction caused by increased mitochondrial DNA mutation rate during the aging process. Our study points to the determinant role of mitochondria in aging
We found that airway ciliary beat frequency in aged C57BL/6 mice was lower than that of the young mice significantly ,and the transplantation of mitochondria derived from younger or older airway epithelial cells can significantly improve the airway cilia beat frequency in aged C57BL/6 mice.We also identified the mechanisms underlying the effects of transplanted mitochondria, which was associated with the mitochondrial dysfunction caused by increased mitochondrial DNA mutation rate during the aging process. Our study points to the determinant role of mitochondria in aging