Canine Renal Dysplasia
An autosomal-dominant disease characterized by delayed maturation of renal tissue. This leads to renal degeneration, protein-losing nephropathy and prolonged renal disease. A genetic predisposition is seen in the Bull terrier, Carin terrier and German Shepherd. Early onset of the disease is rare and is typically seen over the age of 5.
The penetrance of Renal Dysplasia is low and small percentages are clinically affected. The percentage of fetal glomeruli from a renal wedge biopsy is unpredictable. Some adults appear normal but can pass on the disease to offspring while with others signs may not show up before the dog dies from another cause. Around 3-5% of adults with one or two copies of the mutation die
An autosomal-dominant disease characterized by delayed maturation of renal tissue. This leads to renal degeneration, protein-losing nephropathy and prolonged renal disease. A genetic predisposition is seen in the Bull terrier, Carin terrier and German Shepherd. Early onset of the disease is rare and is typically seen over the age of 5.
The penetrance of Renal Dysplasia is low and small percentages are clinically affected. The percentage of fetal glomeruli from a renal wedge biopsy is unpredictable. Some adults appear normal but can pass on the disease to offspring while with others signs may not show up before the dog dies from another cause. Around 3-5% of adults with one or two copies of the mutation die