More than half the subjects with hemophilia A have the severe form of hemophilia. Bleeds caused by hemophilia can occur internally, into muscles and joints, or externally, from minor cuts, trauma, and even dental procedures. How frequently a person bleeds and the severity of those bleeds strongly depends on how much FVIII is in the subject’s blood.
Mild hemophilia A is 6 % all the way up to 49% of FVII in the blood. Patients with mild hemophilia A generally experience excessive bleeding after serious injury, surgery, or trauma. Very often, it’s not diagnosed until a subject has suffered prolonged bleeding as result of the experiences/actions listed before.
Moderate hemophilia A is 1% to 5% of FVIII in the blood. Moderate hemophilia A subjects tend to have bleeding episodes after injuries. Bleeds that occur without obvious causes are called spontaneous bleeding episodes. These can happen with Moderate hemophilia A.
The most dangerous form of hemophilia is Severe hemophilia A. It’s caused by less than 1% of FVIII in the blood. Patients with severe hemophilia A experience bleeding following most injury and have frequent spontaneous bleeding episodes, often internally into their joints and