Clozapine

Due to the controversy of using atypical and typical antipsychotic drugs on patients with chronic schizophrenia, this meta-analysis will focus on the debate over which type of drug helps reduce symptoms more effectively. Using the most common antipsychotics, haloperidol for typical antipsychotic and olanzapine for an atypical antipsychotic, results will be tabulated across a range of scientific studies to conclude which drug has a better outcome of effectiveness for schizophrenic patients. Using the Positive and Negative Syndrome Scale (PANSS), the results will be measured between the two types of drugs and their controls or baseline measurements. Subsections of this paper will evaluate the efficacy of haloperidol and olanzapine on their own on reducing both positive and negative symptoms. Once those are collected, the results of both drugs will be compared to one another to determine which type had the highest decrease in symptoms according to PANSS. Because typical antipsychotics increase negative side effects and the fact that atypical antipsychotics increase levels of neurotrophins, we hypothesize that olanzapine will be more effective than haloperidol in reducing positive and negative symptoms in patients with chronic schizophrenia. INTRODUCTION: Antipsychotic medications are drugs which are used to treat patients with psychosis, mainly for schizophrenia and bipolar disorder. These patients have lost touch with reality and “may hear "voices" or have strange and…

antipsychotics with the first-generation drug, Haloperidol. Due to the limitations of this SSM I will be interpreting results concerning Clozapine and Risperidone exclusively. The comparisons made were regarding efficacy in symptoms, relapse rates, quality of life, side-effects (including EPS and weight gain) and sedation. Both Clozapine and Risperidone had greater efficacy than Haloperidol by 0.52 and 0.13 respectively. This supports the view that second-generation drugs do…

The patient was not at the hearing only the Psychiatrist. Clozapine is an antipsychotic medication that can treat Schizophrenia. Side effects for Clozapine is metabolic syndrome which increased appetite and causes weight gain, hyperglycemia, and hyperlipidemia. Patient will need to tell their Doctor if they are taking herbal products especially St. Johns Wort. Emergency treatment is required if patient is experiencing side effects of agranulocytosis. Before patient goes in treatment as well as…

(Goff 58). By using technology, neuroscientists have found that the brain shrinks during schizophrenia (Goff 58). By the 1950’s new types of treatments and medicines started to be researched and experimented with. Scientists were able to create new drugs. One drug available to help with schizophrenia is Clozapine. “Clozapine has been shown to be more effective than other antipsychotics,” (Spearing 6). A harsh side effect of Clozapine may be getting the condition of “agranulocytosis.”…

Moreover, SGAs, especially clozapine is also efficient in treating those SUs with schizophrenia, who are not responding to other anti-psychotic medications (Gage et al., 2015). It has been proven in clinical trials that those SUs using clozapine showed substantial improvement in their quality of life compared to those on haloperidol (Turner & Stewart, 2006). For example, in my clinical placement, a SU was admitted to our inpatient unit following a relapse from clozapine. His past history clearly…

The patient has chosen to avoid social interactions and to stay in her room rather than leave. She states that she feels tired and exhausted without actually doing anything. The best treatments are simple, make sure the patient does not become more depressed, does not have a change in diet than what is in the norm, and always keep the patient positive. The patient will be prescribed clozapine for the schizoaffective symptoms. Clozapine does not cure this disorder but maintains it. Sertraline…

INTRODUCTION Mankind has been plagued with diseases since the beginning of human existence. Whether it be from environmental factors, genetics, or a combination of both; researchers have tried to solve the mysteries of these maladies. While significant progress has been made in curing several diseases caused by bacteria and viruses, genetic disorders have proven to be a ferocious foe for both technology and human creativity. The complexity, variety, and intensity of these diseases usually…

Co-occurring disorders refer to more complex, challenging, and dangerous clinical picture; therefore require treatment continuity over a long period of time (Cann, 2015) Initially, harm reduction model entails, the interaction of his prescribed medication (Clozapine and anti depressant) and alcohol/marijuana must be evaluated. Taking clozapine and alcohol can together cause dizziness, drowsiness, and difficulty in concentrating and it also impairs judgment (Clozapine and Alcohol, n.d). This…

Medications Because some individuals exhibit more severe symptoms that others, there is not a standardized treatment for schizophrenia. None of the methods available today can cure this disorder and only help to ease the symptoms associated with it. Both antipsychotic and nonantipsychotic drugs and nonpharmacological interventions have all been used in the treatment of schizophrenic symptoms with antipsychotic being the most common method. Antipsychotic medications are a class of drugs used to…

Individuals with schizophrenia health related quality of life may be influenced by factors such as disease symptoms, medication, physical well-being and social interaction (Bebbington, Angermeyer, Azorin, Marwaha, Marteau & Toumi, 2009). Without being treated, symptoms may limit individuals’ normal daily functioning and make social interaction and vocational rehabilitation very challenging. Atypical antipsychotics have been proven to have lower risks of extrapyramidal symptoms, but higher risk…