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1) What are 2 major indications that diastolic function / dysfunction are related to?
2) and you have normal syst func and diast dysfunc?
1) SOB and or HF
2) yes
3) *mean pulm wedge pressure, mean LA pressure, LVEDP, pre A LVEDP
* Change in a predictable progression with myocardial disease such that LVEDP increases prior to the increase in LAP
4)*a) compliant chamber in diastole = filling of the LV from the LA. b) stiff chamber (rapid increase in pressure) in systole - ejection of SV at arterial pressure
* Systole and diastole
Note - the SV must increase with demand with out a huge rise in LAP
5) * at AV closure
* LV pressure fall, rapid filling, diastasis (at slower HRs), atrial contraction
6) Elevation of LV filling pressures....considered elevated when mean pulm wedge pressure > 12mmHg and LVEDP > 16mmHg
Note if exercised induced increase LVFP = limits exercise
7) *mainly -filling and passive properties of the LV wall
* + futher modulated by - incomplete relaxation and variation in diastolic tone
8) *process whereby the myocardium returns after contraction to its unstressed length and force. Normal hearts with a normal load = nearly complete at minimal pressure.
*contraction and relaxation = same molecular process - therefore is controlled by load, inactivation and asynchrony - ie is active
10)* calcium
* due to deleterious interactions between early re-extension in some segments and post systolic shortening of other segments --> delayed global LV relaxation and increased LV filling pressures
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