The Role Of NMDA Receptors In Alzheimer's Disease

Improved Essays
NMDAR role in Alzheimer's disease NMDA receptors have many roles in Alzheimer’s disease, First, it is considered as coincidence detectors its important role in synaptic plasticity in encoding the memories by long-term potentiation (LTP) and long-term depression (LTD)(Butterfield & Pocernich, 2003).There are many factors can affect the synaptic strength or alteration in learning and memory, for example, the number NMDA receptors, Glutamate neurotransmitters in presynaptic and postsynaptic sites, degree of excitability of dendritic and postsynaptic membranes and membrane trafficking(Butterfield & Pocernich, 2003), These factors can cause a cognitive impairment related to the synaptic loss and failure.(Butterfield & Pocernich, 2003) The second

Related Documents

  • Superior Essays

    Since Alzheimer’s disease (AD) was discovered, victims of the disease, family members, and physicians became curious to know more about this now well-known illness. It has inspired many to conduct research to better understand the disease, so this research sets out to examine the pathophysiology of AD. Through this research, the disease was found to be defined as a category of dementia and is analyzed in depth through the understanding of the causes of the disease and how it affects the human body, considering the effects brought upon the brain and what results from them. How an individual is diagnosed with AD is also analyzed along with the treatments that patients may consider once diagnosed. To understand how this disease affects…

    • 2289 Words
    • 10 Pages
    Superior Essays
  • Improved Essays

    Phlomis Umbrosa Essay

    • 896 Words
    • 4 Pages

    Cancer is one of the most life-threatening diseases requiring a lot of development in cures and preventative therapies. A wide variety of anticancer drugs including those that directly or indirectly act on the cells causing cell death have been developed,. Nowadays, natural products have received increasing attention for their potential as novel cancer preventive and therapeutic agents [1,2]. Alzheimer’s disease (AD) is one of the most common causes of mental deterioration in elderly people. It is a progressive degenerative neurological disorder resulting in impaired memory and behavior.…

    • 896 Words
    • 4 Pages
    Improved Essays
  • Decent Essays

    1. Why does the government target Langdon ? Answer : Because they want the information inside the titanium device. 2.…

    • 534 Words
    • 3 Pages
    Decent Essays
  • Improved Essays

    Often times dementia is thought to be an interchangeable term for Alzheimer’s disease. However, dementia and Alzheimer’s disease (AD) are two similar yet different terminologies that should not be used in exchange for the other. Dementia is a broad term that is frequently used to describe people with underlying brain disorders who experience memory, communication and cognitive deficits. Neurodegenerative disease is usually the underlying factor that causes dementia. People who have dementia are affected differently depending on what part of the brain is affected or symptoms worsens over time.…

    • 2199 Words
    • 9 Pages
    Improved Essays
  • Improved Essays

    Currently there are five million Americans living with Alzheimer’s, thus meaning that every 66 seconds someone in the United States develops this memory-snatching disease (). As a matter of fact, Alzheimer’s is the 6th leading cause of death in the United States and kills more than breast and prostate cancer combined (). With these growing statistics, the high stakes of finding a cure is becoming incredibly increased. However, in order for a cure to be discovered the origin of this disease must first be identified.…

    • 1061 Words
    • 5 Pages
    Improved Essays
  • Improved Essays

    Alzheimer's Inequality

    • 1218 Words
    • 5 Pages

    Alzheimer’s disease has a drastic impact on the human population, being one of the most common causes of death. With research less funded than cancer, there are many gaps to be filled. The cure to the disease has not been found yet, however, it is not feasible for me to accomplish such task. I began to look into the causes of Alzheimer’s, and found that research has died down in this area.…

    • 1218 Words
    • 5 Pages
    Improved Essays
  • Improved Essays

    Alzheimer’s disease (AD), was discovered as senile form of dementia in early 1907 by Alois Alzheimer in 1907. Since then the disease has been researched and studied to generate a knowledge base of symptoms, etiology, pathogenesis, treatment and management of the disease. AD is differentiated from senile dementia due to the neurodegenerative process which involves deposits of protein known as amyloid in neurons and neurofibrillary tangles which form plaques. This formation of plaques leads to neuron death and the hardening of tissue leads to progressive and terminal neurological disease state. There has been no cure to Alzheimer’s disease to the complexity of disease and the lack of understanding of amyloid protein and its process.…

    • 791 Words
    • 4 Pages
    Improved Essays
  • Great Essays

    Parkinson's Vs Alzheimers

    • 1977 Words
    • 8 Pages

    Parkinson’s Disease vs. Alzheimer’s Introduction The umbrella term of dementia has upscale of 7 million reported cases in the US a year, however, the symptoms of certain dementias can range from merely forgetfulness to unbearable tremors. To demonstrate the broad spectrum of dementia diseases, Alzheimer’s and Parkinson’s will be juxtaposed. Alzheimer’s disease is generally a memory disabling disease while Parkinson’s disease attacks motor skills. In the following pages an overview of dementia will be described as well as the history of Parkinson’s and Alzheimer’s disease.…

    • 1977 Words
    • 8 Pages
    Great Essays
  • Improved Essays

    Alzheimer's Epidemiology

    • 2584 Words
    • 11 Pages

    Alzheimer’s is a neurodegenerative disease that causes a steady decline of cognitive ability, behavioural and physical capabilities, which can be linked to characteristic pathophysiological changes in the brain. An epidemiological study have found that Alzheimer’s disease is the prominent cause of all dementia cases, accounting for more than 50% or all reported cases of dementia (Dong et al, 2012). The originating cause of this dreadful disease has been determined to be due to not just one factor, but a mixture of different elements such as an individual’s genetic profile, lifestyle and environmental determinants. In the year 1906 Alois Alzheimer preformed his first autopsy of a patient that we now know suffered Alzheimer’s, he discovered extracellular…

    • 2584 Words
    • 11 Pages
    Improved Essays
  • Improved Essays

    With statistics such as these it is surprising that there is not even more research going into AD for a cause and a cure. The authors of the article Advances In Alzheimer's Disease Drug Development say how there is not currently a drug to counteract AD, but all efforts are looking for a…

    • 983 Words
    • 4 Pages
    Improved Essays
  • Improved Essays

    On Alzheimer's Essay

    • 713 Words
    • 3 Pages

    Alzheimers Alzheimer’s, one of the incurable disease affecting hundreds of thousands of people each year. Alzheimer’s is a progressive disease of the brain that slowly causes impairment in memory and other cognitive functions. But how and why does it happen, and can it be cured? Scientist are learning more and more each day about Alzheimer’s and learning more to find a cure for the incurable disease. Also, some people might relate Dementia to Alzheimer’s…

    • 713 Words
    • 3 Pages
    Improved Essays
  • Improved Essays

    Alzheimer's Disease Essay

    • 1248 Words
    • 5 Pages

    The leading factor to cell death and tissue loss of a brain affected by Alzheimer’s is plaques and tangles. These dead nerve cells made up of another protein are known as tangles. In the areas where tangles are formed nutrients and other necessities can no longer move through the cells. This causes a build up of a protein, beta-amyloid, between nerve cells known as plaques. . (Alzheimer’s Disease Genetics)…

    • 1248 Words
    • 5 Pages
    Improved Essays
  • Great Essays

    Alzheimer's Case Study

    • 1472 Words
    • 6 Pages

    According to the Alzheimer’s Association, about five million people in the United States are diagnosed with Alzheimer’s. Alzheimer’s is a type of dementia, or memory loss that can also cause problems with behavior. Anyone can be diagnosed with Alzheimer’s, however, the most common age is 65 and older. Alzheimer’s disrupts the way electrical charges travel in the cells and the activity of neurotransmitters. This causes nerve cells to die, which in turn causes tissue loss.…

    • 1472 Words
    • 6 Pages
    Great Essays
  • Improved Essays

    Many people categorize Alzheimer’s disease as a normal part of the aging process in which most elderly people will probably have. However, this is not the case. Alzheimer’s disease is not a normal part of the aging process. Instead, it is a disease that is associated with brain function. Furthermore, Alzheimer’s is not a sudden onset disease; it develops gradually over time and can slowly progress.…

    • 331 Words
    • 2 Pages
    Improved Essays
  • Superior Essays

    Dementia is diagnosed by the presence of symptoms such as problems with memory, thinking, problem solving, language disturbances and psychological changes. Neurodegenerative changes within the brain, such as neuron death and a build-up of misplaced proteins are causal to the aforementioned symptoms. While an in depth understanding of the neurobiology of dementia has not been established, dementia diseases are characterized by the grade of neuron loss and the irreversible damage within the connections of the brain, combined with the resulting symptoms (Caberlotto and Nguyen, 2014). One of the most common forms of dementia, Alzheimer’s disease, occurs as a result of chemical and degenerative structural changes within the brain. Dementia can also be caused by a number of conditions such as vascular dementia following a stroke, fronto-temporal dementia caused by brain injury or Korsakoff’s syndrome, which is associated with long term excessive drinking.…

    • 1388 Words
    • 6 Pages
    Superior Essays