Myloidosis Essay

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A myloidosis (am-uh-loi-doh-sis) results from mutational folds of the immunoglobulin protein, forming a fibril. A fibril is a product of protein aggregation. It is still unknown what causes these fibrils to form, however scientists know that the folds are found in the light chains, also known as the Lambda chains. This specific immunoglobulinic amyloidosis is also referred to as AL or “primary” amyloidosis. AL amyloidosis is considered to be the most common type of systemic amyloidosis in western countries. AL amyloidosis is usually a systemic disease, characterized by these fibril proteins depositing into multiple organs. Renal manifestations are the most frequent, affecting two-thirds of patients at the time of diagnosis. Amyloid proteins can deposit in the kidney and cause a range of issues from heavy proteinuria to nephrotic syndrome and impaired renal …show more content…
If the results are positive for a presence of free lambda light chains in the urine and an absence of monoclonal gammopathy, this is indicative of Amyloidosis. A subcutaneous fat aspirate will be performed and sent to the pathology lab for confirmatory tests. A pathologist will review the abdominal fat biopsy and if the aspirate is negative, then an invasive biopsy of the suspected organ must be performed to confirm or exclude the disease. *If negative, the tissue biopsy will *The tissue will be stained with Congo Red. This will stain a type of protein called an amyloid, found in patients with amyloidosis. A patient’s diagnosis relies on pathological examination of Congo red-positive amyloid deposits, which present as typical apple-green birefringence under polarized light using immunofluorescence (Desport, et al., 2012). The presence of the green color under a polarizing microscope confirms that the patient is positive for amyloids, indicating

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