Drug release from NODS was slow, sustained and significantly better as compared to suspension. Also, the second example of novel delivery system is related to the liposomes. Cyclic RCG liposome loaded with edaravone was one of them. This type of liposome was proved to be useful for antidepressant–like effect in experimental rats. Next, submicron-sized liposome (ssLips) loaded with edaravone was found to be helpful in reduction of the number of cell death which was induced by the In-vivo N-methyl-d-aspartate. Also, retinal protection effects of ssLips containing edaravone was found to be more significant than free edaravone. Furthermore, microemulsion containing edaravone was also established. The components inside the microemulsion should be carefully selected so that the potential to maximize the solubility of edaravone in gastrointestinal fluid could be
Drug release from NODS was slow, sustained and significantly better as compared to suspension. Also, the second example of novel delivery system is related to the liposomes. Cyclic RCG liposome loaded with edaravone was one of them. This type of liposome was proved to be useful for antidepressant–like effect in experimental rats. Next, submicron-sized liposome (ssLips) loaded with edaravone was found to be helpful in reduction of the number of cell death which was induced by the In-vivo N-methyl-d-aspartate. Also, retinal protection effects of ssLips containing edaravone was found to be more significant than free edaravone. Furthermore, microemulsion containing edaravone was also established. The components inside the microemulsion should be carefully selected so that the potential to maximize the solubility of edaravone in gastrointestinal fluid could be