Half-life is prolonged in infants with cholestatic hepatitis.” http://www.unitypoint.org/blankchildrens/filesimages/for%20providers/nicu%20medications/caffeine%20citrate%20therapy.pdf Neonates have slow metabolism when first born, but as they age metabolism increases (lexi-drugs). Therefore, it is given once daily and does not need dose adjustment in hepatic and renal failure( lexi-drugs). Acording to Bikash et all., the elimination half-life starts to decrease from birth and reaches the adult values at 60 weeks' post-conception age. Since there is limited data regarding the pharmacokinetics of caffeine administration in neonates with hepatic or renal impairment, caffeine should be administered with caution in this group of patients, so toxic levels are avoided. According to Bikash Shrestha and Gaurav Jawa et all, in preterm neonates, the predominant process of caffeine metabolism is N7 demethylation, which increases exponentially with postnatal age, and is maintained up to 38 weeks until the maturity of the liver.
Half-life is prolonged in infants with cholestatic hepatitis.” http://www.unitypoint.org/blankchildrens/filesimages/for%20providers/nicu%20medications/caffeine%20citrate%20therapy.pdf Neonates have slow metabolism when first born, but as they age metabolism increases (lexi-drugs). Therefore, it is given once daily and does not need dose adjustment in hepatic and renal failure( lexi-drugs). Acording to Bikash et all., the elimination half-life starts to decrease from birth and reaches the adult values at 60 weeks' post-conception age. Since there is limited data regarding the pharmacokinetics of caffeine administration in neonates with hepatic or renal impairment, caffeine should be administered with caution in this group of patients, so toxic levels are avoided. According to Bikash Shrestha and Gaurav Jawa et all, in preterm neonates, the predominant process of caffeine metabolism is N7 demethylation, which increases exponentially with postnatal age, and is maintained up to 38 weeks until the maturity of the liver.