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Neural Plasticity
The ability of the nervous system to be modified after birth.
How does neural plasticity effect synapse signalling?
It causes changes that can strengthen or weaken signalling at a synapse.
What are the steps of LTP?
One or more axons fire a rapid series of stimuli.
The burst of stimulation leaves some of the synapses potentiated for minutes, days, or weeks.
2
What is so special about a potentiated synapse?
It is more likely to elicit an action potential.
Do stimuli have to generate action potentials in LTP?
No.
How do we know LTP works for learning and memory?
Drugs that impact learning often have parallel effects on LTP.
Learning can produce LTP-like changes.
LTP effects are greatest in brain areas involved in learning and memory.
LTp is elicited by high-frequency electrical stimulation of the presynaptic neuron and mimits normal neural activity.
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What are the three steps of LTP?
Induction (learning)Expression (memory)Maintenance (recall)
3, durr
How do mice show improved learning and memory from LTP?
Mice with little LTP have trouble with MWM. Drugs that enhance LTP can also enhance MWM.
What does Glutamate act on?
The receptors AMPA and NMDA on the postsynaptic membrane
AMPA
A postsynaptic receptor permeable to Na+
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