term1 Definition1term2 Definition2term3 Definition3
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The cardiovascular System:
Heart
Blood Vessels
Lymphatics
Lymph nodes, spleen, "MALT"
RBS
WBC
---Macrophage, T, B, NK, lymphocytes
The blood:
Carries O2, CO2, nutrients, cells, plasma
Infectious agents in the blood
-Bacteremia:
bacteria in the blood
Viremia:
Virus in the blood
Septicemia:
growth of bacteria in blood
Septic Shock:
-->endotoxin (LPS) release
-->macrophage cytokines
-->low blood pressure (leaky capillaries)
-->high fever
Cardiovascular system defenses
-Defensins:
-Neutrophils, antibodies, complement
-Filtering function of Lymph Nodes
-No normal flora
-Transient flora?
-Infectious agents in blood
=systemic infection
-Yersina pestis
Lyme Disease
-Borrelia burgdorferi
Tularemia
-Franscisella tularensis
Yersinia pestis
-Cause of PLAGUE
-Gram negative rod
-Grows in digestive tract of flea = VECTOR
-RESERVOIR are rodents, prairie dogs
-Endemic above 4,000 ft elevation in Arizona and around 4 corners
Plague pandemic
-Black Death
-1348-1350
* some recurrent outbreaks up until 1668
-Reduced Europe's population by about half
-100 million people
-In some towns - 100% mortality
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