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where and when do the limb buds on an embryo occur
week 4 on ventrolateral body wall
what develops from the mesenchymal mesoderm
bones and connective tissue
what develops form the epithelial ectoderm
the digitis (fingers and toes)
the apical ectodermal ridge (AER) is formed through the thickening of the distal border of what kind of ectoderm
epithelial ectoderm
the epithelial ectoderm thickens at its distal border to form the AER, which then surrounds the mesenchyme to form what?
the 'progress zone' (PZ) of undifferentiated rapidly proliferating cells
what is a congenital anomaly
a defect present from birth
out of 10,000 births, how many congenital defects will be in the upper limb
3.4/10,000
out of 10,000 births, how many congenital defects will be in the lower limb
1.1/10,000
what are congenital anomalies often associated with
Often associated with craniofacial, cardiac and/or genitourinary defects.
list the IFSSH classification problems
type I • Failure of formationtype II • Failure of differentiationtype III • Duplicationtype IV • Overgrowthtype V • Undergrowthtype VI • Constriction band syndromestype VII • Generalised anomalies and syndromes
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