CYP3A4 is predominantly found in the liver, however it is also present in other organs and tissues of the body, allowing for greater active sites.2 Therefore no alternations to the metabolism process are needed. Elimination of Sitagliptin occurs primarily through renal excretion, involving active tubular secretion.3 Lowering dosages are recommended in patients with moderate and severe renal insufficiency; Sitagliptin is primarily eliminated unchanged via renal excretion, thus dosage adjustments are required for patients with moderate to severe renal
CYP3A4 is predominantly found in the liver, however it is also present in other organs and tissues of the body, allowing for greater active sites.2 Therefore no alternations to the metabolism process are needed. Elimination of Sitagliptin occurs primarily through renal excretion, involving active tubular secretion.3 Lowering dosages are recommended in patients with moderate and severe renal insufficiency; Sitagliptin is primarily eliminated unchanged via renal excretion, thus dosage adjustments are required for patients with moderate to severe renal