Glucocorticoids have been found to upregulate β2-adrenoceptors that were downregulated. This is achieved by increasing the transcription rate of the beta receptor gene which leads to more receptors and increased sensitivity to β2-agonists (Johnson, 2004). Another study illustrated this effect even after high doses of short-acting β2-agonists which would otherwise have left them desensitised (Hadcock et al., 1989). This is of significant therapeutic importance as it should allow for continued dosage regimens without desensitisation of
Glucocorticoids have been found to upregulate β2-adrenoceptors that were downregulated. This is achieved by increasing the transcription rate of the beta receptor gene which leads to more receptors and increased sensitivity to β2-agonists (Johnson, 2004). Another study illustrated this effect even after high doses of short-acting β2-agonists which would otherwise have left them desensitised (Hadcock et al., 1989). This is of significant therapeutic importance as it should allow for continued dosage regimens without desensitisation of