It has been hypothesized that this elevation in MAO-B is what contributes to the neurodegeneration observed in PD. In 2008, Mallajosyula et al,. tested this hypothesis by conducting a study in which they induced elevated expression of human MAO-B in the astrocytes of adult mice. The results of the study showed that within 2 weeks of inducing MAO-B in adult mice that there was a 50% reduction in the number of dopaminergic neurons. Along with the loss of dopaminergic neurons, these mice had a significant decrease in locomotor function and were exhibiting key symptoms seen in PD (Mallajosyula et al., 2008). In knowing this, it can be concluded that there is a correlation between higher levels of MAO-B expression and the neurodegeneration in
It has been hypothesized that this elevation in MAO-B is what contributes to the neurodegeneration observed in PD. In 2008, Mallajosyula et al,. tested this hypothesis by conducting a study in which they induced elevated expression of human MAO-B in the astrocytes of adult mice. The results of the study showed that within 2 weeks of inducing MAO-B in adult mice that there was a 50% reduction in the number of dopaminergic neurons. Along with the loss of dopaminergic neurons, these mice had a significant decrease in locomotor function and were exhibiting key symptoms seen in PD (Mallajosyula et al., 2008). In knowing this, it can be concluded that there is a correlation between higher levels of MAO-B expression and the neurodegeneration in