[54] had proposed a novel technology for separating the anesthetic effects of propofol and an ultra-short-acting opioid remifentanil, using the spectral features of EEG. By applying a floating search method, a well-performing feature set is achieved to estimate the effects of propofol during induction of anesthesia and to classify whether or not remifentanil has been co-administered. [55] The state of general anesthesia (GA) is associated with an increment of spectral power in scalp electroencephalogram (EEG) at below 40 Hz frequencies, including spectral peaks in the slow oscillation bands. Because conventional power spectral analyses are insensitive to possible cross-frequency coupling, the relationships among the oscillations at different frequencies remain largely unexplored. Quantifying such coupling is essential for improving clinical monitoring of anesthesia and understanding the neuroscience of this brain state. Eran et al. [55] tested the usefulness of measurement of two cross-frequency coupling: the bispectrum derived Synch Fast Slow, which is sensitive to phase-phase coupling in different frequency bands, and modulo gram analysis of coupling between SO phase and alpha rhythm amplitude. Synch Fast Slow, a metric that is used in anesthesia
[54] had proposed a novel technology for separating the anesthetic effects of propofol and an ultra-short-acting opioid remifentanil, using the spectral features of EEG. By applying a floating search method, a well-performing feature set is achieved to estimate the effects of propofol during induction of anesthesia and to classify whether or not remifentanil has been co-administered. [55] The state of general anesthesia (GA) is associated with an increment of spectral power in scalp electroencephalogram (EEG) at below 40 Hz frequencies, including spectral peaks in the slow oscillation bands. Because conventional power spectral analyses are insensitive to possible cross-frequency coupling, the relationships among the oscillations at different frequencies remain largely unexplored. Quantifying such coupling is essential for improving clinical monitoring of anesthesia and understanding the neuroscience of this brain state. Eran et al. [55] tested the usefulness of measurement of two cross-frequency coupling: the bispectrum derived Synch Fast Slow, which is sensitive to phase-phase coupling in different frequency bands, and modulo gram analysis of coupling between SO phase and alpha rhythm amplitude. Synch Fast Slow, a metric that is used in anesthesia