We start with drugs like marijuana and heroin, which cause the brain to lock down our receptors and activate the nerve cells.
Other drugs like cocaine cause drugs to release a lot of dopamine, which can cause problems with the communication channel.
Taking drugs will cause repetitive effects your brain will adjust to the drug effects. repetitive effects can cause you to feel flat, lifesless, and depressed.
The more you do drugs just like everyhing you will create a tolerence which will rrequire you to take a higher dose in able to still feel the "high" you get from drugs. The result