Treatment
The standard first-line treatment for malignant gliomas includes the use of alkylating agents such as temozolomide, which is widely used, sometimes in combination with ionizing radiation (7). This alkylating agents exist in the environment, like in fuel combustion or cigarette smoke, in diet, such as in processed meat or could exist as a product of endogenous metabolic processes (8, 9). This alkylating agents, when in low concentrations, could be mutagenic and carcinogenic but another cause of human exposure to this type of agents is cancer chemotherapy, in which they are choose due to their ability to induce extensive DNA damage and cell death (9). They also can induce a great quantity of DNA lesions because they can react with different…